The prestigious American scientific journal Jama Neurology has published the findings of a glioblastoma research collaboration between the Universities of Padua, Berlin, and Bordeaux, as well as the Veneto Oncology Institute (IOV) of Padua, coordinated by Maurizio Corbetta, professor of Neurology, director of the University Hospital of Padua's Neurological Clinic, and principal investigator of the Veneto Institute of Molecular Medicine (VIMM). The most frequent type of malignant brain tumor is glioblastoma. As a result, there are still no viable treatments. So far, most studies on this disease have concentrated on tumor features (mutations, interactions with the immune system, response to therapy). However, the focus of this study was on the characteristics of the organ in which this tumor develops: the brain. The brain is made up of neurons and a network of fibers that connect brain areas, which is known as the "connectome." As a result, the connections are analogous to roads that connect the various regions of the brain. The group of experts demonstrated in their work that the prognosis of this disease is also and most importantly dependent on the number of structural connections (the bundles of fibers that connect brain areas to each other) in the region where the tumor develops. It has been observed that when the tumor grows in places with high fiber density, survival from the time of diagnosis is shorter, and when the tumor grows in areas with low fiber density, the prognosis is better. The reason for this could be that when a tumor grows in areas with more fibers (i.e. more "roads"), it is more likely to spread to other areas of the brain.