With the arrival of the SpaceX Crew-10 capsule to the International Space Station (ISS) on March 15, two new experiments funded by the Italian Space Agency (ASI) are being launched. Their names are IRIS and Drain Brain 2.0 and they will be worn and tested by international astronauts. This is not the first time that Italian experiments have been carried out on the Space Station by astronauts who do not belong to our country. This privilege stems from agreements made with NASA back in 1997 for the supply of three pressurized modules used to transport materials to and from the ISS. IRIS is carried out by the National Institute of Nuclear Physics - TTLAB together with the University of Bologna and aims to monitor in real time the amount of ionizing radiation received during daily activities by astronauts. The second experiment is the "Drain Brain 2.0" project carried out with the collaboration of the University of Ferrara. During the mission, astronauts will wear an instrument designed to noninvasively detect and monitor some important cardiovascular health parameters.