All-Italian research opens up new opportunities in space medicine. The University of Sassari and the Rinaldi Fontani Institute in Florence presented innovative results at the ISSCR Annual Meeting 2025 in Hong Kong. The team demonstrated the use of REAC (Radio Electric Asymmetric Conveyer) technology to mitigate the adverse effects of microgravity on human stem cells. The study used mesenchymal stem cells from Wharton's jelly that were exposed to simulated microgravity for 24 hours using a three-dimensional rotation machine (3D-RPM). Following exposure, the cells were treated with a special REAC technique known as MO-MG. The result? A significant recovery in the activity of genes critical for stemness maintenance (Oct4, Sox2, Nanog), as well as the activation of epigenetic factors involved in the response to cellular stress. The context makes the study even more significant: as astronaut Luca Parmitano recently stated, a voyage to Mars might result in a 25% loss in bone density in six months, with effects equivalent to accelerated aging. "We require technologies that are capable of not only safeguarding the human body from the harsh conditions of space, but also of improving its regenerative capabilities", stated Salvatore Rinaldi of the Rinaldi Fontani Institute. As per Margherita Maioli, the project leader in Sassari, "the results obtained demonstrate that the REAC treatment is not restricted to the protection of cells; it also reactivates their vital functions".