The international BioRescue consortium, including the University of Padua, has entered a crucial new phase in its mission to save the northern white rhinoceros (Ceratotherium simum cottoni), one of the world’s most endangered species. Since the start of the year, scientists have created three new embryos—a milestone in conservation science—and have begun the first embryo transfers, implanting pure northern white rhino embryos into southern white rhino surrogate mothers. With only two northern white rhinos remaining—females Najin and her daughter Fatu, both unable to carry a pregnancy naturally—BioRescue relies on advanced assisted reproduction techniques and pioneering stem cell applications to give the species a fighting chance. All procedures, including the first embryo transfers, underwent strict ethical review by University of Padua experts. Surrogate mothers showed no adverse health effects, and Fatu, whose eggs provided the embryos, has even benefited from repeated procedures through a process known as ovarian cleansing therapy, improving her ovarian health. The ultimate goal is ambitious but clear: to restore the northern white rhino to its native habitat, giving this iconic species a second chance on the African savanna.