There is no discomfort or anesthesia, and the patient, who was awake throughout the surgery, notices the uncontrollable tremor disappear. This is due to treatment using "high-frequency focused ultrasound guided by magnetic resonance imaging".At the Besta Neurological Institute in Milan, 400 procedures of this nature have been conducted since 2019, when the Ravelli Foundation donated the Exablate Neuro, a €2 million piece of machinery, to the hospital. Now that the Lombardy Region has provided the Institute with cutting-edge technology (Exablate Prime), the number of treatments will be increased. Among other advantages, the new equipment reduces each process from 3.5 hours to around 2 hours. There are just five Exablate Prime devices in Europe. Focused ultrasound has two potential applications in neurological therapy: either to eliminate problematic "foci" in the brain or to increase the permeability of local blood vessels, thereby enabling the passage of medications that would otherwise be inaccessible to the diseased tissue (in this case, a tumor). The first uses targeted ultrasound at high frequencies, while the second uses low frequencies.