Research undertaken together by the CNR-Isc (Institute of Complex Systems) and Sapienza University of Rome has revealed that stem cells construct a "family tree" regulated by an invisible flow of information. Scientists were able to detect this phenomena for the first time by using a physics concept known as inheritance entropy: the substantial variations in skeletal stem cell behavior are not attributable to chance, but rather to a precise biological memory passed down from generation to generation. The discovery, published in the respected journal PRX Life of the American Physical Society, opens up previously unexplored avenues for understanding cellular aging, tissue regeneration, and complicated disorders like cancer. This discovery brings physics and biology together in an unexpected way, and it could have far-reaching consequences for future regenerative medicine.