The Umbrian town of Città di Castello celebrates the return of one of its most precious masterpieces. Raphael’s Standard of the Holy Trinity has officially returned to the Municipal Art Gallery, following an important restoration intervention carried out by the Central Institute for Restoration in Rome and after taking part in the international exhibition “Raphael: Sublime Poetry”, hosted at the Metropolitan Museum of Art in New York. The Standard of the Holy Trinity is one of Raphael's most important works from his early years in Città di Castello. The banner, painted in oil on canvas, depicts two compositions: the Holy Trinity with Saints Sebastian and Roch on one side, and the Creation of Eve on the other. The banner was dismantled in 1628 after deteriorating over time due to its use in religious processions. The work is most likely connected to the Confraternity of the Holy Trinity, founded in 1226, which managed a church and a hospital in Città di Castello. The presence of Saints Sebastian and Roch, who were usually invoked as plague protectors, reflects the city's health and devotional environment in the late 15th and early 16th centuries. Recent reinterpretation of documents concerning the epidemic that afflicted Città di Castello between 1497 and 1499 enables us to situate the Standard at a critical juncture in the city's history and in the early career of the Urbino artist. The Standard's return to the Pinacoteca Comunale represents not only the return of a restored masterpiece, but also a moment of strong identity for Città di Castello: an opportunity to rediscover the city's relationship with the young Raphael, who received some of his first key commissions here and began to establish his name in the Italian Renaissance artistic landscape.